Hypothermic preservation of isolated rat lungs in modified bicarbonate buffer, EuroCollins solution or St Thomas' Hospital cardioplegic solution

Comparison of phosphodiesterase inhibitors of differing isoenzyme selectivity added to St. Thomas' hospital cardioplegic solution used for hypothermic preservation of rat lungs.

Raising intracellular cAMP or cGMP concentrations protects lungs from ischemia-reperfusion injury. These nucleotides are catabolized by a number of distinct phosphodiesterase (PDE) isoenzyme subfamilies. We examined the ability of PDE inhibitors of differing selectivities to protect lungs from the effects of prolonged hypothermic storage. Rat lungs were perfused with bicarbonate buffer mixed wi...

EFFECT OF CYANIDE IN CARDIOPLEGIC SOLUTION ON ISOLATED RAT HEART FUNCTION

It has been known that cardiomyocytes possess a remarkable ability to downregulate their energy expenditure on restricted 02 supply. However it has also been speculated that an ability to suppress aerobic respiration and ATP utilization could be a protective response to prolonged hypoxia. Having the role of the cytochrome oxidase enzyme in mind, one can ask if its inhibition by using cyani...

Comparison of Plegisol and Modified ST Thomas Hospital Cardioplegic Solution in the Development of Ventricular Fibrillation after Declamping of the Aorta

Ventricular fibrillation seen just after declamping of the aorta is an undesirable condition causing myocardial injury. To return to normal rhythm, often internal shocks are applied. But defibrillation itself can also contribute to myocardial injury. So prevention of fibrillation is more important than treatment. 236 patients undergoing coronary artery by-pass surgery were included in this retr...

Cardioplegic solution challenges.

Development of cardioplegic solution without potassium: experimental study in rat

INTRODUCTION Myocardial preservation during open heart surgeries and harvesting for transplant are of great importance. The heart at the end of procedure has to resume its functions as soon as possible. All cardioplegic solutions are based on potassium for induction of cardioplegic arrest. OBJECTIVE To assess a cardioplegic solution with no potassium addition to the formula with two other com...